Circadian Dynamics of Cannabinoids
We would be wise to consider the circadian dynamics of cannabis use if our goal is optimal health. Some reports indicate that cannabis can spike the release of melatonin (which could tied into the sleep promoting properties of cannabis). Melatonin is meant to increase through the night, and then decrease through the day; keeping melatonin high at the wrong times could disrupt our circadian rhythms.
Cannabis also has effects on sleep structure (the amount of time spent in different phases of sleep). In particular, cannabis tends to decrease REM sleep (associated with dreaming) but increase deep sleep. It is of interest that deep sleep is when the brain cleans out the amyloid protein that is associated with alzheimer's disease.