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Celastrol is a compound found in the Thunder God Vine, Tripterygium wilfordii. It is a pentacylic triterpenoid with a structure that resembles steroid hormones. The Thunder God Vine has a long traditional use as an anti-inflammatory.

Molecular structure of Celastrol

In a 2014 study, celastrol was shown to inhibit inflammatory and neuropathic pain. This effect was not seen when celastrol was administered along with SR144528, a compound that selectively blocks the CB2 receptors.

Scientific Research